In June 2018, a potentially carcinogenic nitrosamine impurity, N-nitrosodimethylamine (NDMA), was detected in valsartan, a medication used to treat high blood pressure and heart failure. Soon after, NDMA and further small dialkyl N-nitrosamine impurities were discovered in other sartan active pharmaceutical ingredients (APIs), and later in stomach acid regulator ranitidine, and diabetes medicines piaglitazone and […]
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